Toxicological effects of ziram, thiram, and dithane M‐45 assessed by sperm shape abnormalities in mice

1 April 1993

journal article
research article
Published by Taylor & Francis in Journal of Toxicology and Environmental Health

Vol. 38 (4) , 393-398
https://doi.org/10.1080/15287399309531727

Abstract

The three commonly used dithiocarbamate fungicides ziram, thiram, and dithane M‐45 were investigated for their mutagenic and carcinogenic potency using sperm shape abnormalities in mice. The fungicides were administered intraperitoneally in single and cumulative doses. All three of the fungicides tested were found to induce significant increase in the frequency of abnormal sperm at all the doses, and a linear dose effect was observed.

Keywords

This publication has 7 references indexed in Scilit:

Screening strategy for chemicals that are potential germ-cell mutagens in mammals
Mutation Research/Reviews in Genetic Toxicology, 1983
The detection of carcinogen-induced sperm head abnormalities in mice
Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1980
Increased frequencies of aberrant sperm as indicators of mutagenic damage in mice
Mutation Research/Environmental Mutagenesis and Related Subjects, 1979
Mutagenicity studies on organophosphorus insecticides
Mutation Research/Reviews in Genetic Toxicology, 1975
Chemical induction of sperm abnormalities in mice.
Proceedings of the National Academy of Sciences, 1975
Centriolar changes induced by vinblastine sulphate in the seminiferous epithelium of the mouse
Experimental Cell Research, 1973
Morphogenetic factors influencing the shape of the sperm head
Developmental Biology, 1971