PHARMACOLOGICAL METHODS OF ESTIMATING INHIBITION OF DRUG OXIDATION IN THE MOUSE
Open Access
- 1 June 1959
- journal article
- research article
- Published by Wiley in British Journal of Pharmacology and Chemotherapy
- Vol. 14 (2) , 251-255
- https://doi.org/10.1111/j.1476-5381.1959.tb01394.x
Abstract
Three pharmacological techniques for measuring inhibition of “non-specific” oxidase activity in the mouse are described: (1) potentiation of pentobarbitone hypnosis, (2) potentiation of chlorpromazine hypothermia; and (3) reduction in the toxicity of octamethylpyrophosphorodiamide (schradan). Iproniazid, isoniazid, and β-diethylaminoethyl 3,3-diphenylpropylacetate (SKF 525A) gave comparable results in all three tests.Keywords
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