Insertion of a retrotransposon within the 3' end of a mouse gene provides a new functional polyadenylation signal
- 1 January 1988
- journal article
- research article
- Published by Oxford University Press (OUP) in Nucleic Acids Research
- Vol. 16 (15) , 7241-7251
- https://doi.org/10.1093/nar/16.15.7241
Abstract
A site of genomic insertion of the mouse retrotransposon TLR-IS/MuRRS was analysed. The comparison of the genomic and the cDNA clones indicates the insertion of the LTR-IS element into the 3'' untranslated region of a mous gene. The fact that the isolated cDNA clone ends with a poly A tail 20 nucleotides down stream from the LTR-IS AATAAA box and the result of the S1-nuclease mapping provides evidence that the 3'' end of the mouse gene transcript was generated under the control of the LTR-IS polyadenylation signal.This publication has 24 references indexed in Scilit:
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