In vivo persistence of sister chromatid exchanges (SCE) induced by gamma rays in mouse bone marrow cells

1 January 1984

journal article
research article
Published by Wiley in Environmental Mutagenesis

Vol. 6 (4) , 529-537
https://doi.org/10.1002/em.2860060406

Abstract

The sister chromatid exchange (SCE) frequencies induced in bone marrow cells by in vivo irradiation with gamma rays before or after bromodeoxyuridine (Brdurd) incorporation were compared. The frequency of SCE at different postir‐radiation times was also measured in bone marrow cells in vivo, irradiated before Brdurd incorporation. Increased sensitivity to SCE induction by radiation was found in cells after Brdurd incorporation for one cycle when compared with cells irradiated before Brdurd incorporation. The increased SCE frequency persisted for at least 72 hr after the initial irradiation, implying that the gamma ray‐induced lesion(s) capable of eliciting an SCE are persistent and cannot be easily repaired.

Keywords

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