A Physiologically Based Pharmacokinetic Model for Trichloroethylene and Its Metabolites, Chloral Hydrate, Trichloroacetate, Dichloroacetate, Trichloroethanol, and Trichloroethanol Glucuronide in B6C3F1 Mice
- 30 November 1997
- journal article
- Published by Elsevier in Toxicology and Applied Pharmacology
- Vol. 147 (1) , 15-30
- https://doi.org/10.1006/taap.1997.8190
Abstract
No abstract availableKeywords
This publication has 29 references indexed in Scilit:
- Pharmacokinetic Modeling of Trichloroethylene and Trichloroacetic Acid in HumansRisk Analysis, 1993
- Physiological pharmacokinetic modeling of inhaled trichloroethylene in ratsToxicology and Applied Pharmacology, 1991
- Disposition and pharmacodynamics of dichloroacetate (DCA) and oxalate following oral DCA dosesBiopharmaceutics & Drug Disposition, 1991
- The carcinogenicity of dichloroacetic acid in the male B6C3F1 mouseFundamental and Applied Toxicology, 1991
- Consideration of the Target Organ Toxicity of Trichloroethylene in Terms of Metabolite Toxicity and PharmacokineticsDrug Metabolism Reviews, 1991
- Liver tumor induction in B6C3F1 mice by dichloroacetate and trichloroacetateToxicology, 1990
- Pharmacokinetics for regulatory risk analysis: The case of trichloroethyleneRegulatory Toxicology and Pharmacology, 1988
- Quantitative evaluation of the metabolic interactions between trichloroethylene and 1,1-dichloroethylene in vivo using gas uptake methodsToxicology and Applied Pharmacology, 1987
- Delineation of the role of metabolism in the hepatotoxicity of trichloroethylene and perchloroethylene: A dose-effect studyToxicology and Applied Pharmacology, 1985
- Gas chromatographic determination of chloral hydrate, trichloroethanol and trichloroacetic acid in blood and in urine employing head-space analysisJournal of Chromatography A, 1974