TGF-β SIGNAL TRANSDUCTION
- 1 June 1998
- journal article
- review article
- Published by Annual Reviews in Annual Review of Biochemistry
- Vol. 67 (1) , 753-791
- https://doi.org/10.1146/annurev.biochem.67.1.753
Abstract
The transforming growth factor β (TGF-β) family of growth factors control the development and homeostasis of most tissues in metazoan organisms. Work over the past few years has led to the elucidation of a TGF-β signal transduction network. This network involves receptor serine/threonine kinases at the cell surface and their substrates, the SMAD proteins, which move into the nucleus, where they activate target gene transcription in association with DNA-binding partners. Distinct repertoires of receptors, SMAD proteins, and DNA-binding partners seemingly underlie, in a cell-specific manner, the multifunctional nature of TGF-β and related factors. Mutations in these pathways are the cause of various forms of human cancer and developmental disorders.Keywords
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