Photophysical properties of 5,10,15,20-tetrakis(m-hydroxyphenyl)porphyrin (m-THPP), 5,10,15,20-tetrakis(m-hydroxyphenyl)chlorin (m-THPC) and 5,10,15,20-tetrakis(m-hydroxyphenyl)bacteriochlorin (m-THPBC): a comparative study
- 1 January 1999
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 2
- No. 2,p. 325-328
- https://doi.org/10.1039/a805328f
Abstract
For the tumour photosensitisers m-THPP, m-THPC, and m-THPBC in methanol the following photophysical properties have been measured: absorption and fluorescence spectra, ES, Stokes shift, Φf, ΦT, τT, dioxygen quenching rates, and ΦΔ for air-saturated and oxygen-saturated solutions. The properties of the first excited triplet state are quite uniform across this series. The quantum yields of singlet oxygen formation are high, being 0.43–0.46 in air-saturated methanol, and 0.59–0.62 in oxygen-saturated methanol. For a constant substitution pattern and a standard given light dose, tumour photonecrosis in vivo appears to parallel the product of drug dose and the molar extinction at the irradiation wavelength in the red region of the visible spectrum.Keywords
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