Influence of administration routes of antibiotics on the cecal flora in rats. I.

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Abstract
The influence of administration routes of ampicillin (ABPC) on the weight of the cecum and on the cecal flora was investigated in rats. The concentration of ABPC in the cecal contents after single oral administration or multiple oral administration was higher than that after i.v. or rectal administration. Rather high concentrations of ABPC were observed in cecal contents even after intravenous and rectal administration. The concentrations of of ABPC observed in the cecal contents after administrations by all 3 routes were larger than the minimum inhibitory concentrations of ABPC for all the cecal floral investigated in the present study. Enterobacteriaceae in cecal flora were increased after treatment by all routes of administration and in all dosage schedules. Staphylococci were markedly decreased, except in the case of single dosage treatment. Populations of other bacteria in the cecal contents were not influenced by administration of ABPC. The route of administration did not appear to modify the influence of ABPC on the cecal flora. The weight of the cecum after oral administration of ABPC was markedly increased in comparison with that after i.v. or rectal administration.

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