EFFECTS OF AN ORALLY ACTIVE CONVERTING ENZYME-INHIBITOR (YS-980) ON RENAL-FUNCTION IN DOGS

  • 1 January 1980
    • journal article
    • research article
    • Vol. 214  (1) , 166-170
Abstract
The angiotensin converting enzyme inhibitor is a valuable pharmacological tool for studying the role of intrarenal humoral factors, i.e., the renin-angiotensin and kallikrein-kinin systems and prostaglandsin [PG] as related to the regulation of renal function and the interration among them. An intrarenal infusion of such an inhibitor, YS-980 (thiazolidine carboxylic acid derivative), at a rate of 0.1 mg/min caused a significant fall in systemic arterial blood pressure and a significant increase in renal blood flow, urine flow, urinary Na excretion and renin release in anesthetized dogs. The renal effects evoked by YS-980 were abolished after the inhibition of kallikrein as induced by aprotinin (900 kallikrein inhibitory units/min). In addition, YS-980 given after the administation of indomethacin (5 mg/kg i.v.) had no effect on the renal hemodynamics and renin release except for the urinary excretion of Na. The kallikrein-kinin system and PG contribute to the renal action and the vasodepressor effect of YS-980. The intrarenal administration of the angiotension converting enzyme inhibitor induced marked renal effects through activation of kinin and PG and that the relative contribution of the renin-angiotensin system is negligible in anesthetized dogs.