A Simple Method of Dithioacetal—and Ketalization
- 1 January 1977
- journal article
- research article
- Published by Taylor & Francis in Synthetic Communications
- Vol. 7 (4) , 283-286
- https://doi.org/10.1080/00397917708050748
Abstract
Dithioacetals and ketals are useful synthetic intermediates.1 In general, they are obtained by the acidcatalysed addition of thiol to carbonyl compounds.2 The reaction is however a reversible one, and an excess of thiol together with continuous removal of water are often required for optimum yield. Recently, it was reported3 that methylthiotrimethylsilane converted carbonyl compounds to dithioacetals and ketals. The reaction however can not be applied to other thiols.Keywords
This publication has 2 references indexed in Scilit:
- O-Trimethylsilyl hemithioacetals and ketals. Reaction with organolithiums.Tetrahedron Letters, 1976
- Methylthiotrimethylsilane. Versatile reagent for thioketalization under neutral conditionsJournal of the American Chemical Society, 1975