Powerful Prions?

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Abstract
An important landmark in our conception of viruses was the recognition that viruses can cause diseases that present none of the hallmarks of classic infectious diseases. Perhaps the most extraordinary example of this atypical behavior of "viruses" is exemplified by the group of slow viruses recently termed "prions" by Prusiner and his colleagues and reviewed in this issue of the Journal.1 Veterinarians originally recognized that certain viral diseases such as visna-maedi and scrapie could have very long incubation periods, cause no fever or inflammatory response, and fail to lead to an immune response.2 The similarities between the neuropathologic process . . .

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