Genetic Susceptibility of Mice to Candida albicans Vaginitis Correlates with Host Estrogen Sensitivity
- 1 August 2004
- journal article
- Published by American Society for Microbiology in Infection and Immunity
- Vol. 72 (8) , 4878-80
- https://doi.org/10.1128/iai.72.8.4878-4880.2004
Abstract
We compared susceptibility to Candida vaginitis in derived murine substrains differing in sensitivity to estrogen (CD-1 and CD10, resistant; CD3 and C57BL/6 responsive), and in F1 crosses. The order of decreasing resistance was CD-1 ≥ CD10 ≥ CD10 × CD3F1 > CD10 × B6F1 > CD3 > C57BL/6 and correlated with estrogen responsiveness in endocrine disruptor assays. Resistance to Candida vaginitis appears additive in CD10 × B6F1 animals and dominant in CD10 × CD3F1 animals.Keywords
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