Hyperfibrinogenemia and Thrombocytopenia After Staphylococcal Enterotoxin.

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Abstract
Summary Parenteral injection of staphylo-coccal enterotoxin increased plasma fibrino-gen levels of rabbits and monkeys. The maximum titer of between 2 to 3 times the pre-challenge concentration was attained in 24 hours after enterotoxin administration. Enterotoxin also depressed the blood serotonin concentration of rabbits. This drop in blood serotonin corresponded to the decrease in number of circulating blood platelets. Both antigenic types of enterotoxin tested induced hyperfibrinogenemia and thrombocytopenia. The dosages required to induce a significant change in these two responses was close to the minimal emetic dose for monkeys by the intravenous route.

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