Long‐Term Carcinogenicity Bioassays on Three Chlorofluorocarbons (Trichlorofluoromethane, FC11; Dichlorodifluoromethane, FC12; Chlorodifluoromethane, FC22) Administered by Inhalation to Sprague‐Dawley Rats and Swiss Mice
- 1 June 1988
- journal article
- Published by Wiley in Annals of the New York Academy of Sciences
- Vol. 534 (1) , 261-282
- https://doi.org/10.1111/j.1749-6632.1988.tb30116.x
Abstract
Three propellant chlorofluorocarbons, namely trichlorofluoromethane (FC11), dichlorodifluoromethane (FC12), and chlorodifluoromethane (FC22) were administered by inhalation at a concentration of 5000, 1000 and 0 ppm, 4 hours daily, 5 days weekly, for 104 and 78 weeks, to rats and mice, respectively. The animals were kept under observation until spontaneous death. Under the experimental conditions, all three compounds failed to show any carcinogenic effects.Keywords
This publication has 3 references indexed in Scilit:
- The toxicological evaluation of chlorofluorocarbon 22 (CFC 22)Food and Chemical Toxicology, 1984
- Mutagenicity of a halocarbon refrigerant monochloro-difluoromethane (R-22) in Salmonella typhimuriumToxicology Letters, 1978
- Design and analysis of randomized clinical trials requiring prolonged observation of each patient. II. Analysis and examplesBritish Journal of Cancer, 1977