Salicylanilides: A New Group of Active Uncouplers of Oxidative Phosphorylation

29 December 1967

journal article
research article
Published by American Association for the Advancement of Science (AAAS) in Science

Vol. 158 (3809) , 1694-1695
https://doi.org/10.1126/science.158.3809.1694

Abstract

Investigations using housefly mitochondria revealed several salicylanilide derivatives as the most effective uncoupling agents of oxidative phosphorylation reported so far. Even greater inhibition of the associated P_i-adenosine triphosphate exchange was shown with these compounds in both housefly and rat-liver mitochondria, and close similarity was observed between the two types of organelles.

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