Effects of Glypressin on Human Nasal Mucosa

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Abstract
Bende M, Bake B, Flisberg K, Löth S, Ohlin P, Olsson P, Pipkorn U. Effects of glypressin on human nasal mucosa. Acta Otolaryngol (Stockh) 1986; 102:488–493. The effect of intravenous and topical glypressin, a triglycyl hormonogen of vasopressin, on the nasal mucosa was evaluated in healthy subjects. A dose-dependent reduction of nasal blood flow resulted from both intravenous and topical glypressin. The effect of the latter in gel form lasted 2 hours. Glypressin was also found to decongest the nasal mucosa. Topical application of glypressin gel might be an alternative to conventional treatment with intranasal packing in nose-bleed.