Transcriptional Regulation of Apolipoprotein A5 Gene Expression by the Nuclear Receptor RORα
- 1 June 2005
- journal article
- research article
- Published by Wolters Kluwer Health in Arteriosclerosis, Thrombosis, and Vascular Biology
- Vol. 25 (6) , 1186-1192
- https://doi.org/10.1161/01.atv.0000163841.85333.83
Abstract
Objective— The newly identified apolipoprotein A5 (APOA5), selectively expressed in the liver, is a crucial determinant of plasma triglyceride levels. Because elevated plasma triglyceride concentra... Apolipoprotein A5 has recently been identified as a crucial determinant of plasma triglyceride levels. Our results showed that RORα upregulates human APOA5 but has no effect on mouse apoa5 gene. Th...Keywords
This publication has 26 references indexed in Scilit:
- The Liver X Receptor Ligand T0901317 Down-regulates APOA5 Gene Expression through Activation of SREBP-1cJournal of Biological Chemistry, 2004
- Apolipoprotein C-III, metabolic syndrome, and risk of coronary artery diseaseJournal of Lipid Research, 2003
- Retinoic acid receptor-related orphan receptor (ROR) α4 is the predominant isoform of the nuclear receptor RORα in the liver and is up-regulated by hypoxia in HepG2 human hepatoma cellsBiochemical Journal, 2002
- Expression and regulation of the nuclear receptor RORα in human vascular cellsFEBS Letters, 2001
- Transcriptional Regulation of Apolipoprotein C-III Gene Expression by the Orphan Nuclear Receptor RORαJournal of Biological Chemistry, 2001
- The ExDression Pattern of the Orphan Nuclear Receptor RORβ in the Developing and Adult Rat Nervous System Suggests a Role in the Processing of Sensory Information and in Circadian RhythmEuropean Journal of Neuroscience, 1997
- Transcriptional Regulation of Apolipoprotein A-I Gene Expression by the Nuclear Receptor RORαJournal of Biological Chemistry, 1997
- Disruption of the nuclear hormone receptor RORα in staggerer miceNature, 1996
- ROR-γ: The Third Member of ROR/RZR Orphan Receptor Subfamily That Is Highly Expressed in Skeletal MuscleBiochemical and Biophysical Research Communications, 1994
- Identification of Nuclear Receptor mRNAs by RT-PCR Amplification of Conserved Zinc-Finger Motif SequencesBiochemical and Biophysical Research Communications, 1993