Effects of Serine on Morphine-Dependent Mice

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Abstract
Single doses of serine (250 mg/kg i.p.) failed to elevate brain glycine in mice (1 h after injection), or to compensate for losses caused by implantation of morphine base (70 mg/animal), and reduced the jumping response to nalorphine (100 mg/kg i.p.). Sustained treatment with 250 mg/kg doses of serine at 24-h intervals produced increases in brain and medullar glycine (1 h after 4th injection: 46-50% in normal, 39-75% in morphine-dependent mice) and enhanced the jumping response (40% over controls).