The Biological Effects of Ozone on Man and Animals

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Abstract
Recent literature on the effects of ozone exposures on man and animals is reviewed, with emphasis on the effects of low concentrations of ozone (0.05 to 0.20 ppm). Irritation of the mucous membranes of the upper respiratory tract, a decrease in visual acuity and other changes in ocular parameters, an enhancement in mortality of respiratory infected test animals, the sphering of red blood cells, structural changes in the nuclei of myocardial tissue, and an increase in mortality of newborn animals have been reported within this range. At higher concentrations (0.6 to 0.8 ppm for 2 hours), ozone will interfere with lung function for the duration of exposure and beyond. Other effects of ozone include distinct respiratory distress, coughing, choking and severe fatigue, which occur at concentrations at or below 1.0 ppm (the maximum level of ozone ever measured in dense atmospheric photochemical air pollution).

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