Lengthening the period of a biological clock in Euglena by cycloheximide, an inhibitor of protein synthesis.
- 1 April 1967
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 57 (4) , 1080-1087
- https://doi.org/10.1073/pnas.57.4.1080
Abstract
The period length of the circadian rhythm of phototactic response in Euglena is increased by cycloheximide, an inhibitor of protein synthesis. Furthermore, the effects of the drug are on the biological clock mechanism itself rather than on some parameter controlled by the clock or on some "coupling" mechanism between the clock and the parameter, as confirmed by experiments involving phase-shifting of the oscillation by light. The possible involvement of protein synthesis in the operation of the clock is discussed.This publication has 10 references indexed in Scilit:
- Dependence of chloroplast pigment synthesis on protein synthesis: Effect of actidionePublished by Elsevier ,2004
- The role of the nucleus in the circadian rhythms of Acetabularia mediterraneaBiochimica et Biophysica Acta (BBA) - Biophysics including Photosynthesis, 1966
- Circadian Nature of a Rhythm Expressed by an Invertaseless Strain of Neurospora crassaPlant Physiology, 1966
- Temperatureinfl sse auf die Circadiane Rhythmik von Euglena Gracilis bei Mixotrophie und AutotrophiePlanta, 1966
- Effect of cycloheximide on ribosomal aggregates engaged in protein synthesis in vitroBiochimica et Biophysica Acta (BBA) - Specialized Section on Nucleic Acids and Related Subjects, 1964
- THE INHIBITION OF A BIOLOGICAL CLOCK BY ACTINOMYCIN DProceedings of the National Academy of Sciences, 1962
- Biochemical Aspects of Rhythms: Phase Shifting by ChemicalsCold Spring Harbor Symposia on Quantitative Biology, 1960
- The Effect of Actidione and other Antifungal Agents on Nucleic Acid and Protein Synthesis in Saccharomyces carlsbergensisJournal of General Microbiology, 1958
- TEMPERATURE INDEPENDENCE IN A UNICELLULAR “CLOCK”Proceedings of the National Academy of Sciences, 1956
- ON TEMPERATURE INDEPENDENCE IN THE CLOCK SYSTEM CONTROLLING EMERGENCE TIME IN DROSOPHILAProceedings of the National Academy of Sciences, 1954