PROGRESSIVE PULMONARY HISTOPLASMOSIS WITH BILATERAL RESECTION AND CHEMOTHERAPY

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Abstract
A case of progressive pulmonary histoplasmosis closely resembling reinfection-type cavitary tuberculosis, with an acute pneumonic spread and cavity formation in the contralateral lung, is reported. Surgical excision of the more recently infected tissue (in the right lung) was followed by some dissemination of the process in both lungs, but excision 3 months later of the initially involved tissue (in the left lung) was uncomplicated. The patient is working and apparently free of active disease. MRD-112, given for 90 days following his first operation, apparently exerted a somewhat beneficial effect on the lesions. Streptomycin, isoniazid and PAS probably had a detrimental effect.

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