Comparison of antimalarial efficacy of artemisinin (qinghaosu) and arteether against Plasmodium cynomolgi B infection in monkeys
- 1 January 1989
- journal article
- research article
- Published by Oxford University Press (OUP) in Transactions of the Royal Society of Tropical Medicine and Hygiene
- Vol. 83 (1) , 56-57
- https://doi.org/10.1016/0035-9203(89)90704-9
Abstract
Arteether (30:70 mixture of α and β epimers) used as injectable intramuscular preparation (in neutralized ground-nut oil) had curative action at 5 mg/kg × 3 d against blood-induced Plasmodium cynomolgi B infection in rhesus monkeys, while the curative dose of artemisinin (qinghaosu) oil suspension was 10 mg/ kg × 7 d or 20 mg/kg × 3 d. Parasite clearance with arteether was achieved within 24 h. Neither arteether nor artemisinin exhibited any causal prophylactic or radical curative action up to dose levels of 20 mg/kg against sporozoite-induced P. cynomolgi B infection in rhesus monkeys.Keywords
This publication has 1 reference indexed in Scilit:
- Responses of Sporozoite-Induced and Trophozoite-Induced Infections to Standard Antimalarial DrugsThe American Journal of Tropical Medicine and Hygiene, 1982