HRPT2, a Tumor Suppressor Gene for Hyperparathyroidism-Jaw Tumor Syndrome
- 1 June 2005
- journal article
- review article
- Published by Georg Thieme Verlag KG in Hormone and Metabolic Research
- Vol. 37 (6) , 380-383
- https://doi.org/10.1055/s-2005-870150
Abstract
Hyperparathyroidism-jaw tumor (HPT-JT) syndrome is a familial multi-tumor syndrome resulting from inactivating mutations in the HRPT2 tumor suppressor gene, which encodes a protein product named parafibromin. Here, we will review recent advances in genetic and protein studies on parafibromin, and examine its biological functions.Keywords
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