Ef2: a new LY-3-linked light-chain marker expressed in normal mouse serum immunoglobulin.

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Abstract
A new L chain marker was detected in normal mouse serum immunoglobulin L chains by gel isoelectric focusing [IF]. The marker (Ef2) involved the presence of 2 major and several minor bands in the normal L chain IF profiles. Strains expressing the marker IF bands were designated Igk-Ef2a, whereas those lacking the bands were Igk-Ef2b. The majority of inbred strains were Igk-Ef2a. Strains Igk-Ef2b were NZB/BINJ, BDP/J, C58/J, I/LnJ, CE/J and P/J. The strain distribution of the alleles differed from the distribution of alleles at the Ly-2 and Ly-3 loci, suggesting the new marker may represent a separate locus. Genetic studies showed that Igk-Ef2 locus is closely linked to Igk-Ef1 and Hd loci on chromosome 6, indicating that it is also closely linked to Ly-3. The relative importance of the bnads controlled by the Igk-Ef2 locus suggests that the entire normal L-chain pool could be controlled by as few as 100 such loci.