Epidemiology of Adenocarcinoma of the Kidney2

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Abstract
A case-control study was conducted in 202 patients with renal adenocarcinoma and 394 controls matched for sex, age, race, and hospital. The results were evaluated with other epidemiologic and laboratory findings in the literature. The case-control study showed a significant but moderate association between cigarette smoking and renal adenocarcinoma, though the specific nature of the association was not determined. Male cases included a significantly larger proportion than did controls of persons with prior myocardial infarction. Female cases contained a significantly larger proportion of persons ≥ 20% overweight than did controls. A relationship to marital status was suggested in females. No significant relationship was found with coffee drinking, alcohol consumption, occupational exposure, or previous disease history. From the current epidemiologic and pathophysiologic data, a working hypothesis was derived which suggested that dietary factors, possibly related to a fat and/or cholesterol intake, were involved in the pathogenesis of renal adenocarcinoma.

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