EZH2 Generates a Methyl Degron that Is Recognized by the DCAF1/DDB1/CUL4 E3 Ubiquitin Ligase Complex
Open Access
- 11 October 2012
- journal article
- research article
- Published by Elsevier in Molecular Cell
- Vol. 48 (4) , 572-586
- https://doi.org/10.1016/j.molcel.2012.09.004
Abstract
No abstract availableKeywords
This publication has 39 references indexed in Scilit:
- Coordinated Regulation of Polycomb Group Complexes through microRNAs in CancerCancer Cell, 2011
- EZH2 Promotes Expansion of Breast Tumor Initiating Cells through Activation of RAF1-β-Catenin SignalingCancer Cell, 2011
- Characterization of Nuclear Localization Signal in the N Terminus of CUL4B and Its Essential Role in Cyclin E Degradation and Cell Cycle ProgressionPublished by Elsevier ,2009
- WD40 protein FBW5 promotes ubiquitination of tumor suppressor TSC2 by DDB1–CUL4–ROC1 ligaseGenes & Development, 2008
- SCFβ-TRCP controls oncogenic transformation and neural differentiation through REST degradationNature, 2008
- Pharmacologic disruption of Polycomb-repressive complex 2-mediated gene repression selectively induces apoptosis in cancer cellsGenes & Development, 2007
- DDB1 functions as a linker to recruit receptor WD40 proteins to CUL4–ROC1 ubiquitin ligasesGenes & Development, 2006
- CUL4–DDB1 ubiquitin ligase interacts with multiple WD40-repeat proteins and regulates histone methylationNature Cell Biology, 2006
- Molecular architecture and assembly of the DDB1–CUL4A ubiquitin ligase machineryNature, 2006
- Role of Histone H3 Lysine 27 Methylation in Polycomb-Group SilencingScience, 2002