Follicle-stimulating hormone and spermatogenesis in the adult male

Publisher Website
Google Scholar
Abstract
There is general agreement that follicle-stimulating hormone (FSH) is of critical importance in the initiation and expansion of spermatogenesis in mammals during puberty (e.g. Russell, Alger & Nequin, 1987), but its role in the normal adult male is still debated. Much of this debate has stemmed from the apparently different results obtained in rodents and primates following immunoneutralization of FSH. Thus, passive immunization of adult rats with FSH antibodies was found to have relatively little or no effect on spermatogenesis (Davies, Main, Laurie & Setchell, 1979; Dym, Raj, Lin et al. 1979), whereas there are numerous studies in a variety of non-human primates which show that active or passive immunization against FSH or its β subunit leads to major suppression of spermatogenesis and a considerable reduction in sperm output (e.g. Wickings, Usadel, Dathe & Nieschlag, 1980; Nieschlag & Wickings, 1982; Raj, Murty, Sairam & Talbert, 1982; Srinath, Wickings, Witting &

This publication has 0 references indexed in Scilit: