The Synthesis of C-13 Labeled Vitamin E, [2a-13C]all-rac-a-Tocopherol
- 1 January 1984
- journal article
- research article
- Published by The Japan Institute of Heterocyclic Chemistry in HETEROCYCLES
- Vol. 22 (9) , 1975-1977
- https://doi.org/10.3987/r-1984-09-1975
Abstract
Vitamin E with a 13C-labeled isoprenoid side chain, [2a-13C]all-rac-.alpha.-tocopherol, was synthesized by condensation of trimethylhydroquinone with a mixture of [3a-13C]phytol and its geometrical isomer. The 13C-labeled phytol was prepared using 5,9,13-trimethyltetradecan-1-al as an intermediate and [13C]methyl iodide as a 13C source. The total yield of the labeled .alpha.-tocopherol was 65.4% on the basis of [13C]methyl iodide.Keywords
This publication has 1 reference indexed in Scilit:
- Fat-Soluble Vitamins and Biological MembranesNature, 1964