Abstract
A synthetic route to the production of the pure enantiomers of the ecstasy-analogue N-Ethyl- 3,4-methylenedioxyamphetamine (MDE) and its major metabolites MDA and HME is presented. The crystal and molecular structure of these compounds has been determined by X-ray crystallography. The hydrogen bonding in the crystal lattice is examined and significant differences were found by comparing (R)- and (S)-MDA-HCl.

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