Treatment of Cold Urticaria with Penicillin

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Abstract
A patient with cold urticaria was presented before the Manhattan Dermatological Society by Dr. Charles P. De Feo and extensively discussed (Arch. Derm. 85:784, 1962). More recently, Dr. Thomas B. Fitzpatrick presented a case of essential cold urticaria before the New England Dermatological Society (Arch. Derm. 86:129, 1962). Neither of the presenters nor any of the discussants mentioned the therapeutic suggestion by Dr. Edward H. Mandel, who on the occasion of the presentation of a case of paroxysmal cold hemoglobinuria before the New York Academy of Medicine, Section of Dermatology and Syphilology, reported on the successful control of the disease by injections of penicillin (Arch. Derm. 84:880, 1962). The rationale for the use of penicillin in the treatment of diseases due to sensitivity to cold was stated by Dr. Mandel to be the degradation of penicillin to penicillamine. I realize that this hypothesis is not generally accepted and was

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