Selective ablation of arterial plaque with pulsed dye lasers

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Abstract
One limitation on laser surgery has been excessive damage to normal tissue adjacent to the targeted diseased sites. For example, in laser angioplasty, investigators have caused perforations, aneurysms, spasms, and other forms of inadvertent damage to the arterial wall using cw argon, CO2, and Nd:YAG lasers to ablate obstructions (primarily atherosclerotic plaque). The use of pulsed lasers can reduce thermal diffusion damage; however, they can still cause ablation when accidentally directed at normal tissue. In this study, a selective laser ablative technique is demonstrated by using wavelengths at which there is preferential absorption in the plaque.

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