A chemiluminogenic substrate for N-acetyl-.BETA.-D-glucosaminidase, o-aminophthalylhydrazido-N-acetyl-.BETA.-D-glucosaminide.

1 January 1990

journal article
research article
Published by Pharmaceutical Society of Japan in CHEMICAL & PHARMACEUTICAL BULLETIN

Vol. 38 (5) , 1323-1325
https://doi.org/10.1248/cpb.38.1323

Abstract

A new type of chemiluminogenic substrate for N-acetyl-.beta.-D-glucosaminidase, o-aminophthalylhydrazido-N-acetyl-.beta.-d-glucosaminide, was prepared by incorporating an enzyme-removable substituent, N-acetyl-D-glucosaminide group, into the hydrazide moiety of luminol. This substrate releases luminol upon enzymatic hydrolysis. The enzyme was detected chemiluminescently using this substrate.

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