Efficacyof Sulforaphane in EradicatingHelicobacter pyloriin HumanGastric Xenografts Implanted in NudeMice
Open Access
- 1 December 2003
- journal article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 47 (12) , 3982-3984
- https://doi.org/10.1128/aac.47.12.3982-3984.2003
Abstract
Sulforaphane, an isothiocyanate abundant in the form of its glucosinolate precursor in broccoli sprouts, has shown in vitro activity againstHelicobacter pylori. We evaluated the effect of sulforaphane in vivo against this bacterium by using human gastric xenografts in nude mice.H. pyloriwas completely eradicated in 8 of the 11 sulforaphane-treated grafts. This result suggests that sulforaphane might be beneficial in the treatment ofH. pylori-infected individuals.Keywords
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