Mutations in T-cell antigen receptor genes α and β block thymocyte development at different stages

1 November 1992

journal article
research article
Published by Springer Nature in Nature

Vol. 360 (6401) , 225-231
https://doi.org/10.1038/360225a0

Abstract

Analysis of mice carrying mutant T-cell antigen receptor (TCP) genes indicates that TCP-β gene rearrangement or expression is critical for the differentiation of CD4⁻ CD8⁻ thymocytes to CD4⁺CD8⁺ thymocytes, as well as for the expansion of the pool of CD4⁺CD8⁺ cells. TCR-α is irrelevant in these developmental processes. The development of γδ T cells does not depend on either TCR-α or TCP-β.

Keywords

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