Blockade of interleukin-6 signaling augments regulatory T-cell reconstitution and attenuates the severity of graft-versus-host disease
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Open Access
- 23 July 2009
- journal article
- research article
- Published by American Society of Hematology in Blood
- Vol. 114 (4) , 891-900
- https://doi.org/10.1182/blood-2009-01-197178
Abstract
Graft-versus-host disease (GVHD) is the major complication after allogeneic bone marrow transplantation and is characterized by the overproduction ofKeywords
This publication has 64 references indexed in Scilit:
- Interleukin-23 secretion by donor antigen-presenting cells is critical for organ-specific pathology in graft-versus-host diseaseBlood, 2009
- In vitro–differentiated TH17 cells mediate lethal acute graft-versus-host disease with severe cutaneous and pulmonary pathologic manifestationsBlood, 2009
- Mechanisms and pathologic significances in increase in serum interleukin-6 (IL-6) and soluble IL-6 receptor after administration of an anti–IL-6 receptor antibody, tocilizumab, in patients with rheumatoid arthritis and Castleman diseaseBlood, 2008
- In vivo–activated CD103+CD4+ regulatory T cells ameliorate ongoing chronic graft-versus-host diseaseBlood, 2008
- Absence of donor Th17 leads to augmented Th1 differentiation and exacerbated acute graft-versus-host diseaseBlood, 2008
- IL-6 blockade inhibits the induction of myelin antigen-specific Th17 cells and Th1 cells in experimental autoimmune encephalomyelitisProceedings of the National Academy of Sciences, 2008
- The impact of regulatory T cells on T-cell immunity following hematopoietic cell transplantationBlood, 2008
- Absence of regulatory T-cell control of TH1 and TH17 cells is responsible for the autoimmune-mediated pathology in chronic graft-versus-host diseaseBlood, 2007
- Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cellsNature, 2006
- A new mathematical model for relative quantification in real-time RT-PCRNucleic Acids Research, 2001