Brominated β-Carbolines from the Marine Tunicate Eudistoma album
- 1 April 1992
- journal article
- Published by American Chemical Society (ACS) in Journal of Natural Products
- Vol. 55 (4) , 525-527
- https://doi.org/10.1021/np50082a025
Abstract
Chemical investigation of the cytotoxic EtOH extract of the marine tunicate Eudistoma album led to the isolation of three brominated beta-carbolines which were characterized by their spectral data. Two of them, eudistomin E, which is already known for its potent antiviral activity, and the novel compound eudistalbin A [1], were shown to possess cytotoxic activity (ED50 less than 5.0 ng and 3.2 micrograms/ml respectively) in vitro against the growth of KB human buccal carcinoma cells. The third compound, eudistalbin B [2], is a new inactive natural product.Keywords
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