Lactate in Cerebrospinal Fluid During Muscular Exercise

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Abstract
In anesthetized dogs muscular work was induced by rhythmic electrical stimulation of the muscles of the hind limbs. Lactate levels in blood were markedly increased at the end of a 20 minutes stimulation period. Lactate in CSF showed a slight increase at the end of the 20 minutes stimulation period which became more manifest in the samples taken 20 minutes later. No changes in lactate concentration in CSF were seen in the same time intervals when lactate levels in blood were elevated by means of an intravenous infusion of lactic acid.