Defective DNA repair and increased lethality in ataxia telangiectasia cells exposed to 4-nitroquinoline-1-oxide
- 1 October 1980
- journal article
- research article
- Published by Springer Nature in Nature
- Vol. 287 (5784) , 747-749
- https://doi.org/10.1038/287747a0
Abstract
The survival responses and DNA repair abilities of AT [(ataxia telangiectasia) fibroblast] cells exposed to 4-nitroquinoline-1-oxide (4NQO), a chemical carcinogen whose DNA-damaging properties partially mimic those of ionizing radiation, were determined. Certain AT cell strains show hypersensitivity to inactivation by 4NQO and defective repair of 4NQO-induced adducts in DNA.This publication has 20 references indexed in Scilit:
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