QUANTITATIVE STUDIES OF CELL TYPES IN THE RAT HYPOPHYSIS FOLLOWING UNILATERAL ADRENALECTOMY

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Abstract
Unilateral adrenalectomy of immature male rats results in compensatory hypertrophy of the remaining adrenal gland and a marked increase in percentage of acidophilic cells in the anterior hypophysis. When unilaterally adrenalectomized rats are subjected to lowered environmental temps, these changes are accentuated. It is believed that reduction in circulating adrenal hormone, either by removal of adrenal tissue, or by stress, stimulates an increase in number of pituitary acidophiles, and that these cells secrete adrenocorticotrophic hormone.