Estimation of genetic variation at the DNA level from restriction endonuclease data.

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Abstract
Estimation of the genetic variation in a natural population when the data are obtained by the use of restriction endonucleases. Under the restriction endonuclease technique, a particular DNA segment is considered and cut wherever a recognition sequence appropriate to the endonuclease occurs. Data generated when a random sample of homologous DNA segments is treated in this way with 1 restrictioin endonuclease or a battery of restriction endonucleases were studied. The numbers and sizes of the fragments that result indicate the locations and the frequencies of the recognition sequence (or, with a battery of restriction endonucleases, of each recognition sequence). These frequencies in the sample form the basis for an estimate of the amount of genetic variation in the population.

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