DNA replication studies of human D-group chromosomes in satellite associations

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Abstract
DNA replication studies were carried out on metaphase plates showing satellite associations to determine the association of individual D chromosomes. In a total of 279 D chromosomes involved in satellite associations and identified by autoradiography, it was found that the association of the three members of the D chromosomes was random. In D/D associations no prevalence of homologous combination was observed. In addition, a case of D trisomy and three cases with t(GqDq) (from two unrelated families) were studied. The extra D chromosome in the first case was identified as a No. 13 by the labelling pattern. In the other three cases, the D chromosome involved in the translocation was identified as a No. 14. Studies of satellite associations in these cases are also described.

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