Synthesis, characterization, and anorectic testing of the four stereoisomers of cyclo(histidylproline)
- 1 November 1985
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 28 (11) , 1745-1747
- https://doi.org/10.1021/jm00149a035
Abstract
All four possible stereoisomers of cyclo(histidylproline) were individually synthesized, purified, and characterized. They were each tested for anorectic activity in rats with a free feeding paradigm over 24 h. Contrary to literature reports, none significantly reduced food intake at any time over the test period.Keywords
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