Enhancing Antibody

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Abstract
Parenteral administration of Le and LBNF1 anti-Bf sera prolonged the MST of Bf grafts from 7.6 days to 16 and 14 days, respectively. IgG prepared from these sera were also biologically active but increased mean survival times to less than 13 days. Immersion of Bf grafts in anti-Bf whole serum or IgG also was effective in prolonging survival of Bf grafts. When two Bf grafts, one dipped in anti-Bf serum or IgG and the other undipped, were sutured on neonatal recipients, the dipped graft was enhanced in two-thirds of the trials while the undipped graft was rejected within control times. These results were interpreted to mean that enhancing antibodies were active peripherally either in the skin graft or its draining lymph node. Despite the use of isotopes, direct evidence for binding to the homograft was not obtained.

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