Inhibitory Effects of Lanostane-Type Triterpene Acids, the Components of Poria cocos, on Tumor Promotion by 12-O-Tetradecanoylphorbol-13-Acetate in Two-Stage Carcinogenesis in Mouse Skin
- 1 January 1996
- journal article
- laboratory investigation
- Published by S. Karger AG in Oncology
- Vol. 53 (5) , 382-385
- https://doi.org/10.1159/000227592
Abstract
Pachymic acid, 3-O-acetyl-16 Α-hydroxytrametenolic acid, and poricoic acid B had been isolated from the sclerotium of Poria cocos Wolf. These compounds showed a strong inhibitory activity against 12-O-tetradecanoylphorbol-13-acetate-induced inflammation in mice. At 0.2 µmol/mouse, these compounds markedly inhibited the promoting effect of 12-O-tetradecanoylphorbol-13-acetate (1 µg/mouse) on skin tumor formation following initiation with 7,12-dimethylbenz[a]anthracene (50 µg/mouse).Keywords
This publication has 0 references indexed in Scilit: