The Mobility of Americium Dioxide in the Rat

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Abstract
The mobility of AmO2 in the rat after pulmonary intubation was investigated by administering different particle size ranges of fractionated suspensions. The clearance of Am from lungs to blood and urine is governed principally by its ability to form low MW complexes, probably hydroxides. Am is excreted in the urine in greater quantities than observed following the administration of americium citrate. The metabolic behavior of AmO2 more closely resembles that of a soluble rather than an insoluble compound. Even so, the systemic burden of Am cannot be predicted by applying a fixed factor to cumulative urinary excretion in the early lung clearance phase.

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