Bone Mineral and Calcium Metabolism Before, During and After Treatment of Osteoporosis with 1α-Hydroxyvitamin D3and Calcium

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Abstract
A series of osteoporotic patients treated for 25 mo. (average) with 1.alpha.-hydroxyvitamin D3 (1.alpha.-OHD3) supplemented with Ca were examined for Ca metabolism and bone mineral changes before, during and 12 mo. after cessation of treatment. The bone mineral content, which increased during treatment, showed a decreasing post-treatment tendency. The decrease was more obvious in patients with senile osteoporosis. The levels of serum Ca and PO4 stayed within normal levels. The urinary Ca excretion rate, which also rose during treatment, returned to pre-treatment values after discontinuing treatment. Excretion of urinary PO4, showed a tendency towards further decrease. Serum PTH [parathyroid hormone] stayed within normal levels, while serum alkaline phosphatase, which was depressed during treatment, rose again after treatment. Evidently, a continuous administration of 1.alpha.-OHD3 and Ca increases bone mineral during long-term treatment.