T-CELL SUBSET MODULATION OF BLOOD ERYTHROID BURST-FORMING UNIT PROLIFERATION

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  • 1 January 1983
    • journal article
    • research article
    • Vol. 101  (1) , 53-57
Abstract
Peripheral blood BFU-E [erythroid burst-forming unit] are primitive erythroid progenitor cells that have been reported to exhibit an absolute dependence of T-cells for proliferation in the plasma clot system. The differential effects of TS [T-suppressor] and TH [T-helper] lymphocytes on proliferation of BFU-E were studied. The effect of unfractionated T-cells, TS and TH, on in vitro growth of peripheral blood BFU-E was investigated. Cell populations were negatively selected by treatment with murine monoclonal antibodies (OKT-3, OKT-4, OKT-8) and C''. Proliferation of peripheral blood BFU-E apparently exhibits an absolute requirement for T-cells. The capacity to enhance growth of BFU-E is approximately equal between normal unfractionated T-cells and TS and TH cells. The TH and TS cells defined by the OKT antibodies may not be critical in the modulation of erythroid proliferation.