Experimental neuropathy produced by 2,5-hexanedione--a major metabolite of the neurotoxic industrial solvent methyl n-butyl ketone.
Open Access
- 1 August 1975
- journal article
- research article
- Published by BMJ in Journal of Neurology, Neurosurgery & Psychiatry
- Vol. 38 (8) , 771-775
- https://doi.org/10.1136/jnnp.38.8.771
Abstract
Chronic exposure of rats to 2,5-hexanedione (CH3COCH2CH2COCH3), a major metabolite of the neurotoxic industrial solvent methyl n-buryl ketone (CH3COCH2CH2CH2CH3), has been shown to cause a clinical peripheral neuropathy with dying-back peripheral and central nervous system degeneration characterized by giant axonal swellings filled with neurofilaments. This pattern of disease is similar to that produced by methyl n-butyl ketone.Keywords
This publication has 11 references indexed in Scilit:
- Nervous System Degeneration Produced by the Industrial Solvent Methyl n-Butyl KetoneArchives of Neurology, 1975
- Glue-Sniffing NeuropathyArchives of Neurology, 1975
- Ultrastructural studies of the dying-back process II. The sequestration and removal by Schwann cells and oligodendrocytes of organelles from normal and diseased axonsJournal of Neurocytology, 1974
- Peripheral neuropathy associated with inhalation of methyl-n-butyl ketoneCellular and Molecular Life Sciences, 1974
- Giant Axonal NeuropathyArchives of Neurology, 1974
- A Review of Acrylamide Neurotoxicity Part II. Experimental Animal Neurotoxicity and Pathologic MechanismsCanadian Journal of Neurological Sciences, 1974
- ULTRASTRUCTURAL STUDIES OF THE DYING-BACK PROCESSJournal of Neuropathology and Experimental Neurology, 1974
- Giant axonal neuropathy ? A unique case with segmental neurofilamentous massesActa Neuropathologica, 1972
- The Pathogenesis of Dying-Back PolyneuropathiesJournal of Neuropathology and Experimental Neurology, 1969
- The significance of the "dying back" process in experimental and human neurological disease.1964