Comparison of Hyposmolar and Hyperosmolar Effects on in Vitro Luteinizing Hormone Secretion by Anterior Pituitary Cells
- 1 January 1985
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 178 (1) , 24-28
- https://doi.org/10.3181/00379727-178-41979
Abstract
Perifusion of acutely dispersed [rat] adenohypophyseal cells with hypotonic medium causes an immediate high-amplitude on burst of luteinizing hormone (LH) secretion. The converse study with hyperosmolar solutions was made. Perifusion with hypertonic medium depressed LH secretion; return to isotonicity caused an immediate high-amplitude off burst of LH secretion closely resembling that induced by hypotonic perifusion. The data give further support to the theory that exocytotic secretion may involve expansion of the outer cell membrane, thus drawing secretory granules to the cell surface where their contents are extruded.This publication has 1 reference indexed in Scilit: