Influence of Intraocular Colchicine and Vinblastine on the Cat Iris

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Abstract
Hahnenberger, R.W.Influence of intraocular colchicine and vinblastine on the cat iris. Acta physiol. scand. 1976.98. 425–432.The effect of intravitreally injected colchicine (100 μgand 300μg) and vinblastine (100μg) on function and sensitivity of the cat iris was studiedin vivo. Both antimitotics caused the same effects: The sensitivity to touch of the cornea disappeared after the third day. The normal sensitivity recovered, but after 1 month there was still an anesthetic island in the center of the cornea. The consensual light reflex from the injected to the normal eye declined markedly between 12 and 24 h and was abolished after 4 days. The consensual light reflex from the normal to the injected eye decreased with a similar time course and was completely abolished or strongly reduced after 4–5 days. The function of the sphincter pupillae in the injected eye was reestablished after one month. The affected iris became supersensitive to both pilocarpine and norepine‐phrine. The degree of super sensitivity in the cholinergic system was closely and inversely related to the degree of impaired function. The function of the dilatator pupillae could not be tested. The observed phenomena were most likely due to inhibition of exoplasmic flow in the nerves supplying the iris and cornea.